BAG1 (BCL2-associated athanogene)
نویسندگان
چکیده
Identity Other names: BAG-1, HAP, HAP46, RAP46 HGNC (Hugo): BAG1 Location: 9p13.3 DNA/RNA Description Centromere to telomerase orientation; 7 exons. Transcription 5 alternative transcripts; 1079 nucleotides mRNA. Protein Description Three isoforms generated by alternative translation initiation; 50kDa (BAG-1L), 46kDa (BAG-1M) and 36kDa (BAG-1S)(Yang et al., 1998). Each BAG-1 isoform contains a conserved BAG domain and ubiquitin-like domain, with variation in length of their N-terminal sequences. Expression Expressed ubiquitously and found to be over-expressed in a number of cancers.
منابع مشابه
A plant Bcl-2-associated athanogene is proteolytically activated to confer fungal resistance
The Bcl-2-associated athanogene (BAG) family is a multifunctional group of proteins involved in numerous cellular functions ranging from apoptosis to tumorigenesis. These proteins are evolutionarily conserved and encode a characteristic region known as the BAG domain. BAGs function as adapter proteins forming complexes with signaling molecules and molecular chaperones. In humans, a role for BAG...
متن کاملInvolvement of Bcl-2-associated athanogene (BAG)-family proteins in the neuroprotection by rasagiline.
Rasagiline, a novel monoamine oxidase (MAO)-B inhibitor, has a mild to moderate effect in relieving Parkinson's disease (PD) symptoms as well as unique neuroprotective effects. Previous studies demonstrated rasagiline protect neurons by regulating Bcl-2 family proteins. Our study aimed to study whether Bcl-2-associated athanogene (BAG)-family proteins, which were reported closely associated wit...
متن کاملRole of BCL2-associated athanogene in resistance to platinum-based chemotherapy in non-small-cell lung cancer
The present study aimed to address the pharmacogenetic role of BAG1 in platinum-based chemotherapy in advanced non-small-cell lung cancer (NSCLC) and in cultured human lung adenocarcinoma A549 cells. A total of 108 NSCLC patients (stages I-IIIA) were treated with a standard chemotherapy regimen of cisplatin plus vinorelbine. Additionally, in vitro cultured A549 cells were treated with cisplatin...
متن کاملStructural basis for regulation of the nucleo-cytoplasmic distribution of Bag6 by TRC35.
The metazoan protein BCL2-associated athanogene cochaperone 6 (Bag6) forms a hetero-trimeric complex with ubiquitin-like 4A and transmembrane domain recognition complex 35 (TRC35). This Bag6 complex is involved in tail-anchored protein targeting and various protein quality-control pathways in the cytosol as well as regulating transcription and histone methylation in the nucleus. Here we present...
متن کامل